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Molecular Cell Biology Lodish – 8th Edition


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With its acclaimed author team, cutting-edge content, emphasis on medical relevance, and coverage based on key experiments, Molecular Cell Biology has justly earned an impeccable reputation as an exciting and authoritative text. Avoiding an encyclopedic approach, the book grounds its coverage in the experiments that define our understanding of cell biology, engaging students with the exciting breakthroughs that define the field’s history and point to its future. The authors, all world-class researchers and teachers, incorporate medically relevant examples where appropriate to help illustrate the connections between cell biology and health and human disease.

Part I. Chemical and Molecular Foundations
1. Molecules, Cells, and Model Organisms
Model organisms Chlamydomonas reinhardtii (for study of flagella, chloroplast formation, photosynthesis, and phototaxis) and Plasmodium falciparum (novel organelles and a complex life cycle)

2. Chemical Foundations

3. Protein Structure and Function
Intrinsically disordered proteins
Chaperone-guided folding and updated chaperone structures
Unfolded proteins and the amyloid state and disease
Hydrogen/deuterium exchange mass spectrometry (HXMS)

4. Culturing and Visualizing Cells
Two-photon excitation microscopy
Light sheet microscopy
Super resolution microscopy
3D culture matricies and 3D printing

Part II. Biomembranes, Genes, and Gene Regulation
5. Fundamental Molecular Genetic Mechanisms
Ribosome structural comparison across domains shows conserved core

6. Molecular Genetic Techniques
CRISPR/Cas9 system in bacteria and its application in genomic editing

7. Biomembrane Structure

8. Genes, Genomics, and Chromosomes
Chromosome conformation capture techniques reveal topological domains in chromosome territories within the nucleus

9. Transcriptional Control of Gene Expression
DNase I hypersensitivity mapping reveals cell developmental history
Long non-coding RNAs involved in X-inactivation in mammals
ENCODE databases

10. Post-transcriptional Gene Control
Improved discussion of mRNA degradation pathways and RNA surveillance in the cytoplasm
Nuclear bodies: P bodies, Cajal bodies, histone locus bodies, speckles, paraspeckles, and PML-nuclear bodies

Part III. Cellular Organization and Function
11. Transmembrane Transport of Ions and Small Molecules
GLUT1 molecular model and transport cycle

12. Cellular Energetics

13. Moving Proteins into Membranes and Organelles
Expanded discussion of the pathway for import of PTS1-bearing proteins into the peroxisomal matrix

14. Vesicular Traffic, Secretion, and Endocytosis
Expanded discussion of Rab proteins and their role in vesicle fusion with target membranes

15. Signal Transduction and G Protein–Coupled Receptors
Human G protein-coupled receptors of pharmaceutical importance

16. Signaling Pathways That Control Gene Expression
Wnt concentration gradients in planaria development and regeneration
Inflammatory hormones in adipose cell function and obesity
Regulation of insulin and glucagon function in control of blood glucose

17. Cell Organization and Movement I: Microfilaments
Use of troponins as an indicator of the severity of a heart attack

18. Cell Organization and Movement II: Microtubules and Intermediate Filaments
Neurofilaments and keratins involved in skin integrity, epidermolysus bullosa simplex
New structures and understanding of function of dynein and dynactin

19. The Eukaryotic Cell Cycle
The Hippo pathway
Spindle checkpoint assembly and nondisjunction and aneuploidy in mice, and nondisjunction increases with maternal age

Part IV. Cell Growth and Differentiation
20. Integrating Cells Into Tissues
Expanded discussion of the functions of the extracellular matrix and the role of cells in assembling it
Structure of cadherins and their cis and trans interactions
Cadherins as receptors for Class C rhinoviruses and asthma
Improved discussion of microfibrils in elastic tissue and in LTBP-mediated TGF-B signaling
Tunneling nanotubes
Functions of WAKs in plants as pectin receptors

21. Stem Cells, Cell Asymmetry, and Cell Death
Pluripotency of mouse ES cells and the potential of differentiated cells derived from iPS and ES cells in treating various diseases
Pluripotent ES cells in planaria
Cells in intestinal crypts can dedifferentiate to replenish intestinal stem cells
Cdc42 and feedback loops that control cell polarity

22. Cells of the Nervous System
Prokaryotic voltage-gated Na+ channel structure, allowing comparison with voltage-gated K+ channels
Optogenetics techniques for linking neural circuits with behavior
Mechanisms of synaptic plasticity that govern learning and memory

23. Immunology
Inflammasomes and non-TLR nucleic sensors
Expanded discussion of somatic hypermutation
Improved discussion of the MHC molecule classes, MHC-peptide complexes and their interactions with T-cells
Lineage commitment of T cells
Tumor immunology

24. Cancer
The characteristics of cancer cells and how they differ from normal cells
How carcinogens lead to mutations and how mutations accumulate to cancer

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