Molecular Pharmacology. From DNA to Drug Discovery

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This textbook provides a fresh, comprehensive and accessible introduction to the rapidly expanding field of molecular pharmacology. Adopting a drug target-based, rather than the traditional organ/system based, approach this innovative guide reflects the current advances and research trend towards molecular based drug design, derived from a detailed understanding of chemical responses in the body. Drugs are then tailored to fit a treatment profile, rather than the traditional method of ‘trial and error’ drug discovery which focuses on testing chemicals on animals or cell cultures and matching their effects to treatments.

1 Introduction to Drug Targets and Molecular Pharmacology
2 Molecular Cloning of Drug Targets
3 G Protein-coupled Receptors
4 Ion Channels
5 Transporter Proteins
6 Cystic Fibrosis: Alternative Approaches to the Treatment of a Genetic Disease
7 Pharmacogenomics
8 Transcription Factors and Gene Expression
9 Cellular Calcium
10 Genetic Engineering of Mice
11 Signalling Complexes: Protein-protein Interactions and Lipid Rafts
12 Recombinant Proteins and Immunotherapeutics
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